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Association of close-range contact patterns with SARS-CoV-2: a household transmission study
7 months ago
Association of close-range contact patterns with SARS-CoV-2: a household transmission study

A new article has been published in eLife Journal: "Association of close-range contact patterns with SARS-CoV-2: a household transmission study"

Abstract

 

Background: Households are an important location for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission, especially during periods when travel and work was restricted to essential services. We aimed to assess the association of close-range contact patterns with SARSCoV-2 transmission.

Methods: We deployed proximity sensors for two weeks to measure face-to-face interactions between household members after SARS-CoV-2 was identified in the household, in South Africa, 2020–2021. We calculated the duration, frequency, and average duration of close-range proximity events with SARS-CoV-2 index cases. We assessed the association of contact parameters with SARSCoV-2 transmission using mixed effects logistic regression accounting for index and household member characteristics.

Results: We included 340 individuals (88 SARS-CoV-2 index cases and 252 household members). On multivariable analysis, factors associated with SARS-CoV-2 acquisition were index cases with minimum Ct value <30 (aOR 16.8 95% CI 3.1–93.1) vs >35, and female contacts (aOR 2.5 95% CI 1.3–5.0). No contact parameters were associated with acquisition (aOR 1.0–1.1) for any of the duration, frequency, cumulative time in contact, or average duration parameters.

Conclusions: We did not find an association between close-range proximity events and SARS-CoV-2 household transmission. Our findings may be due to study limitations, that droplet-mediated transmission during close-proximity contacts plays a smaller role than airborne transmission of SARSCoV-2 in the household, or due to high contact rates in households.

 

Find the full article here!